Regeneron Pharmaceuticals, Inc.
Tarrytown, New York, United States
Job type: fulltime
Job industry: Science & Technology
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.
The Bioassay C Group in the Therapeutic Proteins Department seeks a Scientist to design and perform experiments for in vitro characterization of preclinical and clinical drug candidates in Regeneron's pipeline. The ideal candidate will have experience with assays to evaluate antibody effector function, cytokine release and proliferation. Responsibilities will also include development of cell-based assays to measure the biological activity of protein reagents and monoclonal antibodies (e.g. cytotoxicity assays and luciferase reporter assays) for transfer to a QC environment. A strong background in cell biology and an understanding of signaling pathways is essential. Experience with flow cytometry, stable cell line generation, clonal cell line generation, and bioassay automation (Hamilton) is preferred. Must be able to identify assay problems and design experiments to determine sources of assay variability. Candidate must be able to work comfortably in a fast-paced, collaborative environment, and be able to conduct multiple experiments in parallel. A PhD degree in cell biology, biochemistry or related field with 0-4 years post-graduate experience is required.
-Develop methods to characterize antibody effector function activity in primary cells (characterize receptor expression, effects on cytokine release, proliferation, and ADCC/CDC).
-Develop product-specific potency assays. Optimize assays for transfer to manufacturing division. This may require single cell cloning of stable cell lines, evaluating multiple variables to assess assay stability, and implementation of automation for sample testing
-Stable cell line generation via plasmid based and viral-based methodologies
-Present results within and outside of the group
- Plan experiments and documentation to meet program deadlines
-Assist in generating pharmacology reports to support regulatory filings.
-Write potency assay transmittals for transfer to QC.
-PhD with 0-4 years of experience
-Cell Culture (adherent and non-adherent cells)
-Luciferase Reporter Assays
-Cell Proliferation Assays
-Primary cell assays (cytokine release, proliferation, ADCC, CDC)
-Excellent Communication Skills, including writing skills
-Ability to manage multiple projects simultaneously
This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.
To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.