Lead Bioprocess Engineer
Cardiff City, Cardiff, United Kingdom
Job type: fulltime
Job industry: Education
Job title Lead Bioprocess Engineer
Reporting to CTO
Responsible for Day to day oversight of manufacturing operations and supervision of other staff
Background and Context
A Biotech micro-SME, founded in 2013 and built on biochemical and bioprocess engineering expertise from the University of Bath, and cell and organoid biology expertise from Cardiff University. They are currently developing and commercialising new technologies for applications in drug discovery and genetics research, and will expand the offering for personalised medicine and regenerative medicine in the future. Their focus is on the use of 3D cell culture, in particular the scaled up growth and expansion of organoids (3D multi-cellular structures that, when grown in vitro, can recapitulate a realistic in vivo microanatomy).
This post will be responsible for overseeing, operating, and continuously improving the bioprocess. The successful candidate will be able to understand, modify and troubleshoot the bioprocess as a whole and also understand at depth and intervene on the individual process steps, and to delegate as and when required. They pride themselves on quality and the post will lead the progression from medium scale to larger scale expansion including the attainment of quality standards and applying methods for continuous improvement. The candidate will regularly interact with collaboration partners from the pharmaceutical industry, the biotechnology industry and academia. The post holder will be able to integrate bioprocess knowledge, gene expression, mutation and phenotypic response data and will make key contributions to an integrated plan that will focus on customer needs.
They pride themselves on quality and the post will lead by example in fostering a culture of technical and organisational quality based on teamwork, compliance, inclusivity, and the highest level of product quality. The post will lead manufacturing, reporting to the CTO, and will be involved with the hiring, training, and line management of process engineers, biological scientists and technicians. The successful candidate must demonstrate exemplary teamwork and leadership skills of the highest ethical standard, be able to strategically plan product development and manufacturing operations, and will work closely with other departments to meet customer demands.
The successful candidate will have excellent written and presentation skills, be able to maintain standards while working under pressure, multi-task, and be able to develop technical and transferable skills in others.
- A minimum of BEng degree in chemical engineering, biochemical engineering or related technical field
- A minimum of 5-8 years experience working in biomanufacturing including experience in process monitoring and control, and mammalian cell culture.
- Working knowledge of regulations and GMP systems?
- Excellent ability to organise and prioritise own workload
- Project management skills including strategic planning and budget planning
- Excellent leadership and mentoring skills
- Excellent ability to communicate with various stakeholders using a variety of methods
- Excellent oral, interpersonal and written communication skills
- Proficiency in practical bioprocessing skills
- Proficiency in IT skills (e.g. word, excel, gProms)
- Innovation and developing creative solutions
- Enthusiasm and self-motivation.
- Organisation - able to plan and deliver work to meet required deadlines
- Tenacity and resilience - working to achieve own and team objectives and to overcome obstacles
- Excellent ability to be an effective team worker
- Calm under pressure
- High integrity
- Working knowledge of process improvement methodologies such as Lean or Six Sigma
- Experience with online tools for process monitoring and improvement
Main Duties and Responsibilities
Responsible to the CTO
- Produce organoids for customers. Take a lead in the design and continuous improvement of the bioprocess.
- Ensure cGMP documentation is correct and present and be responsible for maintain the quality standards for the expansion of organoids. Seek to increase the level of quality in the process
- Enable technology transfer from the research team into the manufacturing team.
- Line manage the manufacturing team and support the CTO in managing the research team.
- Occasionally travel alone and globally to meet with stakeholders
- Continually update knowledge and understanding in the field to support the development of the company.
- Identify sources of funding and provide assistance with preparing bids to funding bodies contribute to securing of funds for industry-academic and industry-industry collaboration such as InnovateUK bids.
- Contribute to the strategic direction of the company
- Support and stand if for the CTO as and when necessary.
- Represent the company and actively support public engagement efforts.
Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.